Hybrizyme DELFIA PCB-XL food test is the subject of paper published
in Food Additives and Contaminants..........

Hybrizyme Corporation's Delfia PCB-XL food test is the subject of a paper printed in the
international academic journal Food Additives and Contaminants. The paper was written
based upon work done at the European Union's, European Commission, DG Joint Research,
Institute for Health and Consumer Protection, Food Products and Consumer Goods Unit, located
in Ispra, Italy.

According to the paper, while the production of PCBs has been banned they are still ubiquitous
in the environment. Human contamination is generally through ingestation of contaminated food.
Even though there are strict European-wide regulations concerning PCBs, there have been
recent widespread food contaminations, which were very expensive to contain and required
immediate actions to protect public health.

The study upon which the paper reports proposed an immunoassay as a screen for the rapid
detection of PCBs. Other attributes of using an immunoassay would be high sample throughput,
minimal use of hazardous solvents, and a great cost savings over gas chromatographic analysis.

In conclusion the paper states....."The DELFIA immunoassay allows a fast and simple semi-
quantitative determination of PCBs in the tested matrix. Moreover, the method does not
require extensive sample cleanup or the large amounts of solvents used by conventional methods
thus, ensuring a more cost-effective, simpler and safer operation. The present method also offers
good reliability and repeatability at the PCB concentrations of interest. The technology allows the
GC/MS to be used for confirmation purpose only and provides, therefore, an attractive tool."

The paper was printed in Food Additives and Contaminants, 2001, Vol. 18, No. 2, 121-127. It
is titled "Use of an immunoassay as a means to detect polychlorinated biphenyls in animal fat". The
authors are, S. Jaborek-Hugo, C. von Holst, R. Allen, T. Stewart, J. Willey, and E Anklam.

Reprints of the paper can be obtained from the publisher, Taylor & Frances LTD, or by requesting
a copy from Hybrizyme.